Despite the availability of different first-line drugs and conventional treatments for skin disorders, not all of them provide efficient results without side effects. For this reason, plant-based active ingredients are being investigated as an alternative treatment to ameliorate the symptoms of patients who have this type of diseases. This video will explain in detail the pathogenesis of three skin diseases: psoriasis [1] , prurigo nodularis [5] and vitiligo [9] in order to understand how the compounds derived from some spices improve their symptoms.
References
1. Zhang, S., Wang, J., Liu, L., Sun, X., Zhou, Y., Chen, S., Lu, Y., Cai, X., Hu, M., Yan, G., Miao, X., & Li, X. (2022). Efficacy and safety of curcumin in psoriasis: preclinical and clinical evidence and possible mechanisms. In Frontiers in Pharmacology (Vol. 13). Frontiers Media SA. https://doi.org/10.3389/fphar.2022.903160
2. Rendon, A., & Schäkel, K. (2019). Psoriasis Pathogenesis and Treatment. In International Journal of Molecular Sciences (Vol. 20, Issue 6, p. 1475). MDPI AG. https://doi.org/10.3390/ijms20061475
3. Laura, V., Mattia, F., Roberta, G., Federico, I., Emi, D., Chiara, T., Luca, B., & Elena, C. (2019). Potential of Curcumin in Skin Disorders. In Nutrients (Vol. 11, Issue 9, p. 2169). MDPI AG. https://doi.org/10.3390/nu11092169
4. Bahraini, P., Rajabi, M., Mansouri, P., Sarafian, G., Chalangari, R., & Azizian, Z. (2018). Turmeric tonic as a treatment in scalp psoriasis: A randomized placebo-control clinical trial. In Journal of Cosmetic Dermatology (Vol. 17, Issue 3, pp. 461–466). Wiley. https://doi.org/10.1111/jocd.1251
5. Williams, K. A., Huang, A. H., Belzberg, M., & Kwatra, S. G. (2020). Prurigo nodularis. In Journal of the American Academy of Dermatology (Vol. 83, Issue 6, pp. 1567–1575). Elsevier BV. https://doi.org/10.1016/j.jaad.2020.04.182
6. Gooding, S. M. D., Canter, P. H., Coelho, H. F., Boddy, K., & Ernst, E. (2010). Systematic review of topical capsaicin in the treatment of pruritus. In International Journal of Dermatology (Vol. 49, Issue 8, pp. 858–865). Wiley. https://doi.org/10.1111/j.1365-4632.2010.04537.x
7. Ständer, S., Luger, T., & Metze, D. (2001). Treatment of prurigo nodularis with topical capsaicin. In Journal of the American Academy of Dermatology (Vol. 44, Issue 3, pp. 471–478). Elsevier BV. https://doi.org/10.1067/mjd.2001.110059
8. Singh, M., Kotnis, A., Jadeja, S. D., Mondal, A., Mansuri, M. S., & Begum, R. (2018). Cytokines: the yin and yang of vitiligo pathogenesis. In Expert Review of Clinical Immunology (Vol. 15, Issue 2, pp. 177–188). Informa UK Limited. https://doi.org/10.1080/1744666x.2019.1550358
9. Mihăilă, B., Dinică, R., Tatu, A., & Buzia, O. (2018). New insights in vitiligo treatments using bioactive compounds from Piper nigrum. In Experimental and Therapeutic Medicine. Spandidos Publications. https://doi.org/10.3892/etm.2018.6977
10. Shafiee, A., Hoormand, M., Shahidi-Dadras, M., & Abadi, A. (2018). The effect of topical piperine combined with narrowband UVB on vitiligo treatment: A clinical trial study. In Phytotherapy Research (Vol. 32, Issue 9, pp. 1812–1817). Wiley. https://doi.org/10.1002/ptr.6116